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In preclinical models, researchers observed that AOD9604 does not stimulate IGF-1 production or activate the growth hormone receptor, distinguishing it from full-length hGH
These trials, REDEFINE 1 and REDEFINE 2, published in the New England Journal of Medicine in 2025, involved thousands of participants
Increases in calcitonin levels have been observed in some patients, though the clinical significance remains uncertain
Smith, J., et al
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